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Unfolded protein response: Pro-survival clock sUPRession - Nature.com


Nature.com
The unfolded protein response (UPR) is activated by various stresses to support cell survival or to induce apoptosis, but how the UPR is integrated with other cellular pathways to coordinate cell fate is poorly understood. Bu et al. now show that ...

Dysregulation of Apoptosis

South San Francisco, CA - United States

Apoptosis (programmed cell death) is a key process in cancer development and progression. The ability of cancer cells to avoid apoptosis and continue to proliferate is one of the fundamental hallmarks of cancer and is a major target of cancer therapy development. Developing novel molecules that promote apoptosis by targeting both the intrinsic and extrinsic apoptotic pathways advances our understanding of the mechanisms behind tumor cell proliferation, which may also lead to the development of effective cancer therapies.

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Apoptosis
United States

Aims to stimulate both research on the basis of mechanisms of apoptosis and on its role in various human disease processes.

Apoptosis World
United States

Resources for researchers, with information and links to manufacturers' assay kits, protocols, literature reviews, and site-submission.

Apoptosis in Renal Diseases
United States

Paper reviewing the current knowledge on the regulation of apoptosis with particular emphasis on renal cell death and apoptosis role in triggering renal disease.

Apoptosis Glossary Version 1.3
United States

Provides researchers, new to the study of apoptosis, with the most up-to-date information on the many molecules involved in apoptotic pathways.

United Kingdom

Describes and illustrates the roles of caspases and the bcl-2 family, and discusses the potential therapeutic benefits of suppression/induction of apoptosis. Includes cv, research interests and contacts for author at University of Leeds, England.

Kimball's Biology Pages: Apoptosis
United States

Outlines the mechanisms of cell suicide.

Neuromuscular Disease Center: Apoptosis
United States

Offers profiles of disease related proteins.

United Kingdom

An overview of apoptosis with particularly emphasis on the roles that nitric oxide plays in regulating the process.

Austria

Workgroup at the University of Graz. Provides details of lab members, publications, research, teaching and open positions.

United States

Human neutrophils are constantly produced in the marrow and released into the blood to search for invading pathogens. Apoptosis AnimationAfter only one day, they "commit suicide" and are replaced by younger cells. Beginning with the typical neutrophil shape, the apoptotic neutrophil in the clip above undergoes a series of changes including violent membrane blebbing, called zeiosis, (animation to the right) and fragmentation of DNA creating a vacu