Biology News
Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells - Science


Science
Cell differentiation is often accompanied by metabolic changes. Yang et al. report that generation of double-positive (DP) thymocytes from double-negative (DN) cells coincides with dynamic regulation of glycolytic and oxidative metabolism. Given the ...
Science Daily

Alternative splicing is crucial to muscle mass maintenance - Science Daily


Science Daily
"A number of cell signaling and metabolic pathways have been studied regarding their involvement in sustaining adult muscle mass, but not alternative splicing," said Dr. Thomas Cooper, professor of pathology & immunology, of molecular and cellular ...

Researchers Discover Llama-Derived Nanobody Can Be Used as Potential Therapy for Hard-to-Treat Diseases - Newswise (press release)


Newswise (press release)
In a recent study published in Nature Communications, Sahil Gulati, of the Department of Pharmacology at Case Western Reserve School of Medicine, and colleagues identified a nanobody derived from a llama that targets signaling of G protein-coupled ...

Redox Signaling

Carmel - United States

Overview the role of free radicals and other electronically-activated as cellular messengers, and its relevance to human disease conditions in stroke and alopecia.

Related
BioCarta: Signaling Pathways
United States

Research-oriented biotech company; website offers illustrations and charts of pathways in metabolism, signal transduction, and immunology.

Cell Signaling Pathways
United States

Educational resource to browse or download powerpoint slides, on apoptosis, cell cycle, cytokines, growth factors, gene regulation, ion channels, neurotransmission, and the role of nitric oxide. Links to technical support and customer services of Sigma-Aldrich Co.

Cell Signaling Technology, Inc.
United States

Phospho-specific Antibodies and other Innovative Discovery Tools for Cell Signaling Research.

Canada

Web-based software for creating, editing, annotating, and storing biological signaling pathways, doing consistency checks when integrating data from multiple sources, producing biomolecular network maps, and integrating pathways with protein-protein interaction data.

United States

Guide to bioinformatic resources and annotations from San Francisco State University.

Canada

Research on growth factor transforming and GPI-linked receptors, with links to relevant references. Includes profiles of group members at NRC Biotechnology Research Institute, Canada.

United Kingdom

Introduction to the micromanipulated delivery of zymosan, links to publications, and profiles of members in Department of Surgery, UWCM, Cardiff, Wales.

Hedgehog Signaling Glossary
United States

Resource of research, primarily on fruit fly, for a pathway conserved in all animals, responsible for differentiation of insect segments, wings and limbs. Includes details for submission at Northwestern University, Evanston, IL.

Signaling and Functional Genomics
Germany

Pathway research on RNAi during innate immune responses. Includes recent publications and external links.

Signaling Pathways: Angiogenesis
United States

Angiogenesis results in the formation of new blood vessels, and can be induced by tumor growth, tissue wound, and inflammation. Rapid tumor cell growth creates intracellular hypoxia. Hypoxia-inducible factor (HIF) is a transcription factor that responds to changing intracellular oxygen concentration. Under typical oxygen levels (normoxia), HIF is hydroxylated and acetylated, modifications that target the transcription factor for VHL mediated ubiq